CSKA, who upset Sevilla in the previous round, gave away no signs of stage fright in the early exchanges, with Milos Krasic making a good break down the right straight after kickoff.
Inter, without suspended centre back Lucio and midfielder Thiago Motta, looked to be struggling to find a way through the Russians' defensive maze.
"Today's result could not have been better, but it could have been worse," said CSKA coach Leonid Slutsky, adding that he does not think his club's artificial pitch will give them a big advantage in the second leg.
"The synthetic pitch will not be fundamental for the teams. It has never been unfavourable to our rivals," he added.
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