Manchester United [ Images ] will be getting used to life without Wayne Rooney [ Images ] at home to Bursaspor in the Champions League [ Images ] on Wednesday when holders Inter Milan [ Images ] unleash red-hot Samuel Eto'o on Tottenham Hotspur [ Images ].

Rooney has shocked United by saying he wants to leave but manager Alex Ferguson [ Images ] will not have to make an awkward decision about playing him against the Turkish side after the club said the England [ Images ] striker had gone down with an ankle injury.

Rangers also host Valencia in Group C.

Eto'o scored a hat-trick in his last Group A game against Werder Bremen [ Images ] and will be licking his lips as he comes up against an injury-hit Spurs defence at the San Siro.

Dutch champions Twente Enschede and Werder have some catching up to do in the other group clash.

Barcelona [ Images ] have doubts over Xavi's [ Images ] fitness for the home game with Group D leaders FC Copenhagen while pointless Panathinaikos take on Rubin Kazan.

Group B pacesetters Olympique Lyon [ Images ], with Brazil [ Images ] full back Michel Bastos in surprise goalscoring form, entertain Benfica's [ Images ] South American legion with Schalke 04 and the in-from Klaas-Jan Huntelaar welcoming Hapoel Tel-Aviv.