Lyon made it 2-1 courtesy of Brazilian winger Michel Bastos around the half hour and a Lisandro penalty 13 minutes from time gave them a significant advantage over French champions Bordeaux, who ended Lyon's seven-year reign at the top of Ligue 1 last year.
Bordeaux have the edge over Lyon in Ligue 1 this season but the home side, who have reached the quarter-finals three times before, showed their greater Champions League experience with this victory.
Olympique Lyon's Michel Bastos (right) celebrates after scoring against Bordeaux
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