At Soccer City, the Mexicans have to contend not only with a frenzy of patriotic fervour but also the ear-splitting din of the vuvuzela trumpets, so loud they can make communication between players and coaches almost impossible.
Once mocked even by their compatriots as hopeless under-achievers, and still one of the lowest-rated World Cup hosts, at 83rd in the rankings, South Africa come off a run of 12 unbeaten matches and are new national idols.
A string of comparatively minor crimes against journalists and three Greek players in recent days have highlighted risks in one of the globe's most violent countries outside a war zone.
Six people were injured in a crowd crush at Cape Town's main World Cup fan zone on Thursday when thousands tried to get in.
The death of Mandela's great grand-daughter, a day after three British tourists died in a bus crash, highlighted the fact visitors face as much danger on the roads as from crime.
In Friday's other Group A game, France will be under pressure against Uruguay in Cape Town after unimpressive warm-up games, culminating in a worrying 1-0 defeat by China.
Les Bleus look a far cry from the dominant team that won the World Cup in 1998 and Euro 2000. Uruguay, though unfancied, have had impressive wins against Switzerland and Israel.
With no team outside Europe and South American ever having won a World Cup, Spain are the bookies' favourite, while Brazil are the fans' choice according to a new poll.
Mexican soccer fans hold a banner during the opening ceremony of the 2010 World Cup at Soccer City stadium
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