Federer's loss was even more of a bombshell as he had reached the semi-final of each of the last 23 Grand Slams, an incredible sequence dating back to 2004 when he lost in the third round at Roland Garros to Gustavo Kuerten.
Come Sunday, if Nadal goes on to reclaim his title, Federer could even lose his World No 1 ranking but he still managed to find some humour to lighten the mood.
"They all come to an end at some stage," their Swiss said after a lengthy wait at doping control. "You hope it doesn't happen, but they do. I mean, it was a great run. Now I've got the quarter-final streak going, I guess.
"Conditions were on the rough (side) but he came up with some great tennis," added Federer.
Fifth seed Soderling thoroughly deserved his victory, a reward for persistence if ever there was one.
He has clearly acquired a taste for battering egos.
Soderling will start as favourite in his semi-final against Czech Tomas Berdych who will make a long overdue appearance in the last four of a grand slam tournament after a straight sets thrashing of Russia's Mikhail Youzhny.
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