Coach Pep Guardiola, without the injured Andres Iniesta but with former Inter striker Zlatan Ibrahimovic and left back Eric Abidal back in his squad, has plenty of time to mull tactics.
In recent games, Guardiola has dropped one forward in his habitual attacking trident in favour of a full back, Daniel Alves or Maxwell, who have played in an advanced role to help combat opponents' attempts to crowd the midfield.
Meticulous Inter coach Jose Mourinho will have taken note of how Espanyol successfully harried and disrupted Barca's creative department, keeping Messi and Xavi largely under wraps with close man-to-man marking.
Media reports have therefore speculated Mourinho could make another surprise tactical move for Tuesday after the way his unexpectedly attacking line-up stifled Chelsea.
Right back Maicon may be asked to play in a more advanced role to pack the midfield like Barca, some reports have said.
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